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Displaying record number 667

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MAb ID	multiple MAbs
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine component	gp120

Notes

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When gp120 was used as an immunogen, in contrast to gp120 bound to an anti-V3 MAb, few MAbs were generated and all bound better to the native than to the denatured protein -- MAbs generated were: G1B12, G2F7, G9G8, G12F12, G1B8, G11F11, G9E8, G1B11, G1B6, G6F2, G2E7. Denisova1996

References

Showing 1 of 1 reference.

Denisova1996 G. Denisova, B. Stern, D. Raviv, J. Zwickel, N. I. Smorodinsky, and J. M. Gershoni. Humoral Immune Response to Immunocomplexed HIV Envelope Glycoprotein 120. AIDS Res. Hum. Retroviruses, 12:901-909, 1996. Mice were injected with the gp120 in different configurations: free, complexed with CD4, and as an immunocomplex bound to a V3 loop MAb (M77) of the protein. Polyclonal sera, as well as monoclonal antibodies produced in each case, were analyzed. The free gp120 and gp120-CD4 complex immunogens stimulated responses were directed mainly toward conformational epitopes, but gp120 immunocomplexed with MAb M77 also produced numerous and varied MAbs directed toward linear epitopes that were presumably inaccessible on the gp120, gp120-CD4 proteins. PubMed ID: 8798975. Show all entries for this paper.