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MAb ID	50-61A
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS
Neutralizing	L
Species (Isotype)	human(IgGκ)
Patient
Immunogen	HIV-1 infection
Keywords	binding affinity, review, variant cross-reactivity

Notes

Showing 2 of 2 notes.

50-61A: This review summarizes MAbs directed to HIV-1 Env. There are 51 CD4BS MAbs and Fabs in the database; most, like this MAb, neutralize TCLA strains only. Gorny2003 (review)
50-61A: Neutralizes lab strains LAI and SF2 -- competes with sera from 45 seropositive subjects -- binding affinity 2.4 × 10^-10 M. Fevrier1995 (variant cross-reactivity, binding affinity)

References

Showing 2 of 2 references.

Fevrier1995 M. Fevrier, F. Boudet, A. Deslandres, and J. Theze. Two New Human Monoclonal Antibodies against HIV Type 1 Glycoprotein 120: Characterization and Neutralizing Activities against HIV Type 1 Strains. AIDS Res. Hum. Retroviruses, 11:491-500, 1995. PubMed ID: 7543271. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.