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Displaying record number 582

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MAb ID GV1G2
HXB2 Location Env(494-499)
DNA(7704..7721)
Env Epitope Map
Author Location gp120(494-499 IIIB)
Epitope LGVAPT Epitope Alignment
LGVAPT epitope logo
Ab Type gp120 C5
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein-Ab complex
Vaccine component gp120-Mab complex

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Denisova1996 G. Denisova, B. Stern, D. Raviv, J. Zwickel, N. I. Smorodinsky, and J. M. Gershoni. Humoral Immune Response to Immunocomplexed HIV Envelope Glycoprotein 120. AIDS Res. Hum. Retroviruses, 12:901-909, 1996. Mice were injected with the gp120 in different configurations: free, complexed with CD4, and as an immunocomplex bound to a V3 loop MAb (M77) of the protein. Polyclonal sera, as well as monoclonal antibodies produced in each case, were analyzed. The free gp120 and gp120-CD4 complex immunogens stimulated responses were directed mainly toward conformational epitopes, but gp120 immunocomplexed with MAb M77 also produced numerous and varied MAbs directed toward linear epitopes that were presumably inaccessible on the gp120, gp120-CD4 proteins. PubMed ID: 8798975. Show all entries for this paper.


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