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Displaying record number 547

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MAb ID	G45-60
HXB2 Location	gp160(431-440) DNA(7515..7544)	gp160 Epitope Map
Author Location	gp120(429-438 BRU)
Epitope	GKAMYAPPIS	Epitope Alignment
Ab Type	gp120 C4
Neutralizing	L
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 4 of 4 notes.

• G45-60: The sulfated polysaccharide curdlan sulfate (CRDS) binds to the Envelope of T-tropic viruses and neutralizes virus CRDS inhibits G45-60 binding. Jagodzinski1996
• G45-60: Non-reciprocal enhancement of G45-60 binding by some C1 and C5 antibodies -- reciprocal enhancement of some V2 region MAbs -- reciprocal inhibition with many MAbs that bind to the V3, C4 and CD4 binding site regions. Moore1996
• G45-60: Enhances binding of anti-V2 MAb 697-D. Gorny1994
• G45-60: C4 region -- binds HXB2 20mer KQIINMWQKVGKAMYAPPI, decapeptide flanking peptides also bound -- bound equivalently to native and denatured gp120 -- 433A/L and 435Y/H (not 430V/S) substitutions impaired binding. Moore1993c

References

Showing 5 of 5 references.

Sun1989 N. C. Sun, D. D. Ho, C. R. Y. Sun, R.-S. Liou, W. Gordon, M. S. C. Fung, X. L. Li, R. C. Ting, T.-H. Lee, N. T. Chang, and T. W. Chang. Generation and Characterization of Monoclonal Antibodies to the Putative CD4-Binding Domain of Human Immunodeficiency Virus Type 1 gp120. J. Virol., 63:3579-3585, 1989. PubMed ID: 2474670. Show all entries for this paper.

Moore1993c J. P. Moore, M. Thali, B. A. Jameson, F. Vignaux, G. K. Lewis, S.-W. Poon, M. S. Fung, P. J. Durda, L. Akerblom, B. Wahren, D. D. Ho, Q. J. Sattentau, and J. Sodroski. Immunochemical Analysis of the gp120 Surface Glycoprotein of Human Immunodeficiency Virus Type 1: Probing the Structure of the C4 and V4 Domains and the Interaction of the C4 Domain with the V3 Loop. J. Virol., 73:4785-4796, 1993. General observations: C4 and V3 MAbs are sensitive to the way the epitopes are presented, and this sensitivity cannot be correlated to peptide binding. Some V3-C4 domain interaction was indicated based on mutation and interference studies. PubMed ID: 7687303. Show all entries for this paper.

Gorny1994 M. K. Gorny, J. P. Moore, A. J. Conley, S. Karwowska, J. Sodroski, C. Williams, S. Burda, L. J. Boots, and S. Zolla-Pazner. Human Anti-V2 Monoclonal Antibody That Neutralizes Primary but Not Laboratory Isolates of Human Immunodeficiency Virus Type 1. J. Virol., 68:8312-8320, 1994. Detailed characterization of the MAb 697-D. PubMed ID: 7525987. Show all entries for this paper.

Moore1996 J. P. Moore and J. Sodroski. Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein. J. Virol., 70:1863-1872, 1996. 46 anti-gp120 monomer MAbs were used to create a competition matrix, and MAb competition groups were defined. The data suggests that there are two faces of the gp120 glycoprotein: a face occupied by the CD4BS, which is presumably also exposed on the oligomeric envelope glycoprotein complex, and a second face which is presumably inaccessible on the oligomer and interacts with a number of nonneutralizing antibodies. PubMed ID: 8627711. Show all entries for this paper.

Jagodzinski1996 P. P. Jagodzinski, J. Wustner, D. Kmieciak, T. J. Wasik, A. Fertala, A. L. Sieron, M. Takahashi, T. Tsuji, T. Mimura, M. S. Fung, M. K. Gorny, M. Kloczewiak, Y. Kaneko, and D. Kozbor. Role of the V2, V3, and CD4-Binding Domains of GP120 in Curdlan Sulfate Neutralization Sensitivity of HIV-1 during Infection of T Lymphocytes. Virology, 226:217-227, 1996. PubMed ID: 8955041. Show all entries for this paper.