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Displaying record number 538

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MAb ID	MO86/C3
HXB2 Location	gp160(429-443) DNA(7509..7553)	gp160 Epitope Map
Author Location	gp120(429-443)
Epitope	EVGKAMYAPPISGQI	Epitope Alignment
Ab Type	gp120 C4
Neutralizing
Species (Isotype)	human(IgM)
Patient
Immunogen	in vitro stimulation or selection
Keywords

Notes

Showing 2 of 2 notes.

• MO86/C3: Similarity level of the MO86/C3 binding site pentapeptide KAMYA to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 0 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
• MO86: Generated in response to IIIB Env 286-467 upon in vitro stimulation of uninfected-donor lymphocytes. Ohlin1992

References

Showing 2 of 2 references.

Ohlin1992 M. Ohlin, J. Hinkula, P.-A. Broliden, R. Grunow, C. A. K. Borrebaeck, and B. Wahren. Human MoAbs Produced from Normal, HIV-1-Negative Donors and Specific for Glycoprotein gp120 of the HIV-1 Envelope. Clin. Exp. Immunol., 89:290-295, 1992. PubMed ID: 1379134. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.