HIV molecular immunology database
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|Gag Epitope Map|
|Author Location||p24(152-172 SIVmac)|
|Vaccine type||inactivated HIV|
|Vaccine strain||B clade AGM TYO-7|
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Otteken1992 A. Otteken, S. Nick, W. Bergter, G. Voss, A.C. Faisst, C. Stahl-Hennig, and G. Hunsmann. Identification of a gag protein epitope conserved among all four groups of primate immunodeficiency viruses by using monoclonal antibodies. J. Gen. Virol., 73:2721-2724, 1992. Anti-SIVagmTYO-7 Mabs were obtained by intraperitoneal immunization of mice. Two reacted with p17 and three with p24. The anti-p24 MAbs recognized an epitope present in SIVagmTYO-7, SIVagmTYO-5, and HIV-2/SIVmac. The anti-p17 recognized an epitope present in SIVagmTYO-7, SIVagmTYO-5, HIV-2/SIVmac, SIVagmTYO-1, HIV-1, and SIVmnd. This study shows that the matrix protein expresses at least one highly conserved epitope. PubMed ID: 1383399. Show all entries for this paper.