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MAb ID 9205 (NEA-9205 NEA9205)
HXB2 Location gp160(315-317)
DNA(7167..7175)
gp160 Epitope Map
Author Location gp120( IIIB)
Research Contact NEN, Boston MA, commercial
Epitope RAF Epitope Alignment
RAF epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords variant cross-reactivity

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component Env V3

Notes

Showing 8 of 8 notes.

References

Showing 9 of 9 references.

Durda1990 P. J. Durda, L. Bacheler, P. Clapham, A. M. Jenoski, B. Leece, T. J. Matthews, A. McKnight, R. Pomerantz, M. Rayner, and K. J. Weinhold. HIV-1 Neutralizing Monoclonal Antibodies Induced by a Synthetic Peptide. AIDS Res. Hum. Retroviruses, 6:1115, 1990. PubMed ID: 1702301. Show all entries for this paper.

Trujillo1993 J. R. Trujillo, M. F. McLane, T.-H. Lee, and M. Essex. Molecular Mimicry between the Human Immunodeficiency Virus Type 1 gp120 V3 Loop and Human Brain Proteins. J. Virol., 67:7711-7715, 1993. PubMed ID: 8230494. Show all entries for this paper.

Allaway1993 G. P. Allaway, A. M. Ryder, G. A. Beaudry, and P. J. Madden. Synergistic inhibition of HIV-1 envelope-mediated cell fusion by CD4-based molecules in combination with antibodies to gp120 or gp41. AIDS Res. Hum. Retroviruses, 9:581-587, 1993. PubMed ID: 8369162. Show all entries for this paper.

VanCott1994 T. C. VanCott, F. R. Bethke, V. R. Polonis, M. K. Gorny, S. Zolla-Pazner, R. R. Redfield, and D. L. Birx. Dissociation Rate of Antibody-gp120 Binding Interactions Is Predictive of V3-Mediated Neutralization of HIV-1. J. Immunol., 153:449-459, 1994. Using surface plasmon resonance it was found that the rate of the dissociation of the MAb-gp120 complex, but not the association rate, correlated with MAbs ability to neutralize homologous virus (measured by 50\% inhibition of p24 production). Association constants were similar for all MAbs tested, varying less than 4-fold. Dissociation rate constants were quite variable, with 100-fold differences observed. PubMed ID: 7515931. Show all entries for this paper.

Fontenot1995 J. D. Fontenot, T. C. VanCott, B. S. Parekh, C. P. Pau, J. R. George, D. L. Birx, S. Zolla-Pazner, M. K. Gorny, and J. M. Gatewood. Presentation of HIV V3 Loop Epitopes for Enhanced Antigenicity, Immunogenicity and Diagnostic Potential. AIDS, 9:1121-1129, 1995. PubMed ID: 8519447. Show all entries for this paper.

Schonning1998 K. Schonning, A. Bolmstedt, J. Novotny, O. S. Lund, S. Olofsson, and J. E. Hansen. Induction of Antibodies against Epitopes Inaccessible on the HIV Type 1 Envelope Oligomer by Immunization with Recombinant Monomeric Glycoprotein 120. AIDS Res. Hum. Retroviruses, 14:1451-1456, 1998. PubMed ID: 9824323. Show all entries for this paper.

Schonning1999 K. Schonning, O. Lund, O. S. Lund, and J. E. Hansen. Stoichiometry of monoclonal antibody neutralization of T-cell line-adapted human immunodeficiency virus type 1. J. Virol., 73:8364-8370, 1999. PubMed ID: 10482587. Show all entries for this paper.

Gram2002 G. J. Gram, A. Bolmstedt, K. Schonning, M. Biller, J.-E. S. Hansen, and S. Olofsson. Detection of Orientation-Specific Anti-gp120 Antibodies by a New N-Glycanase Protection Assay. APMIS, 110(2):123-131, Feb 2002. PubMed ID: 12064867. Show all entries for this paper.

Huskens2007 Dana Huskens, Kristel Van Laethem, Kurt Vermeire, Jan Balzarini, and Dominique Schols. Resistance of HIV-1 to the Broadly HIV-1-Neutralizing, Anti-Carbohydrate Antibody 2G12. Virology, 360(2):294-304, 10 Apr 2007. PubMed ID: 17123566. Show all entries for this paper.


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