HIV molecular immunology database
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|Gag Epitope Map|
|Author Location||p24(134-153 IIIB)|
|Vaccine type||beta-galactosidase fusion protein|
|Vaccine strain||B clade IIIB|
|Vaccine component||p24 Gag|
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Niedrig1991 M. Niedrig, J. Hinkula, H.-P. Harthus, M. Broker, L. Hopp, G. Pauli, and B. Wahren. Characterization of murine monoclonal antibodies directed against the core proteins of human immunodeficiency virus types 1 and 2. J. Virol., 65:4529-4533, 1991. Multiple anti-HIV p24 MAbs were generated using HIV-1 IIIB p24 or HIV-2 ROD p26 as immunogens. The epitopes for these MAbs were mapped, and the cross-reactivity between HIV-1 IIIB, HIV-2 ROD and SIV MAC antigens were compared using multiple antibody binding assays. While some of the antibodies raised were cross-reactive by some or all of the assays, (ELISA, WB, immunofluorescence, immunoprecipitation and alkaline phosphatase anti-alkaline phosphatase assay), the different assays often gave different results. Only the antibodies raised to HIV-1 IIIB p24 are included in this database. PubMed ID: 1712863. Show all entries for this paper.