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MAb ID | CAP256V2LS | |
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HXB2 Location | Env | Env Epitope Map |
Author Location | gp160 | |
Epitope |
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Subtype | C | |
Ab Type | gp120 V2 // V2 glycan(V2g) // V2 apex | |
Neutralizing | P (tier2) View neutralization details | |
Species (Isotype) | human | |
Patient | CAP256 | |
Immunogen | ||
Keywords | antibody interactions, binding affinity, broad neutralizer, immunoprophylaxis, immunotherapy, neutralization, structure |
Showing 5 of 5 notes.
Showing 5 of 5 references.
Isolation Paper
Zhang2022
Baoshan Zhang, Deepika Gollapudi, Jason Gorman, Sijy O'Dell, Leland F. Damron, Krisha McKee, Mangaiarkarasi Asokan, Eun Sung Yang, Amarendra Pegu, Bob C. Lin, Cara W. Chao, Xuejun Chen, Lucio Gama, Vera B. Ivleva, William H. Law, Cuiping Liu, Mark K. Louder, Stephen D. Schmidt, Chen-Hsiang Shen, Wei Shi, Judith A. Stein, Michael S. Seaman, Adrian B. McDermott, Kevin Carlton, John R. Mascola, Peter D. Kwong, Q. Paula Lei, and Nicole A. Doria-Rose. Engineering of HIV-1 Neutralizing Antibody CAP256V2LS for Manufacturability and Improved Half Life. Sci. Rep., 12(1):17876, 25 Oct 2022. PubMed ID: 36284200.
Show all entries for this paper.
Cai2022 Cindy X. Cai, Nicole A. Doria-Rose, Nicole A. Schneck, Vera B. Ivleva, Brad Tippett, William R. Shadrick, Sarah O'Connell, Jonathan W. Cooper, Zachary Schneiderman, Baoshan Zhang, Daniel B. Gowetski, Daniel Blackstock, Jacob Demirji, Bob C. Lin, Jason Gorman, Tracy Liu, Yile Li, Adrian B. McDermott, Peter D. Kwong, Kevin Carlton, Jason G. Gall, and Q. Paula Lei. Tyrosine O-Sulfation Proteoforms Affect HIV-1 Monoclonal Antibody Potency. Sci. Rep., 12(1):8433, 19 May 2022. PubMed ID: 35589938. Show all entries for this paper.
Ivleva2018 Vera B. Ivleva, Nicole A. Schneck, Deepika Gollapudi, Frank Arnold, Jonathan W. Cooper, and Q. Paula Lei. Investigation of Sequence Clipping and Structural Heterogeneity of an HIV Broadly Neutralizing Antibody by a Comprehensive LC-MS Analysis. J. Am. Soc. Mass Spectrom., 29(7):1512-1523, Jul 2018. PubMed ID: 29736600. Show all entries for this paper.
Mahomed2020 Sharana Mahomed, Nigel Garrett, Quarraisha A. Karim, Nonhlanhla Y. Zuma, Edmund Capparelli, Cheryl Baxter, Tanuja Gengiah, Derseree Archary, Natasha Samsunder, Nicole D. Rose, Penny Moore, Carolyn Williamson, Dan H. Barouch, Patricia E. Fast, Bruno Pozzetto, Catherine Hankins, Kevin Carlton, Julie Ledgerwood, Lynn Morris, John Mascola, and Salim Abdool Karim. Assessing the Safety and Pharmacokinetics of the Anti-HIV Monoclonal Antibody CAP256V2LS Alone and in Combination with VRC07-523LS and PGT121 in South African Women: Study Protocol for the First-in-Human CAPRISA 012B Phase I Clinical Trial. BMJ Open, 10(11):e042247, 26 Nov 2020. PubMed ID: 33243815. Show all entries for this paper.
Zhang2023 Baoshan Zhang, Jason Gorman, Young D. Kwon, Amarendra Pegu, Cara W. Chao, Tracy Liu, Mangaiarkarasi Asokan, Michael F. Bender, Tatsiana Bylund, Leland Damron, Deepika Gollapudi, Paula Lei, Yile Li, Cuiping Liu, Mark K. Louder, Krisha McKee, Adam S. Olia, Reda Rawi, Arne Schon, Shuishu Wang, Eun Sung Yang, Yongping Yang, Kevin Carlton, Nicole A. Doria-Rose, Lawrence Shapiro, Michael S. Seaman, John R. Mascola, and Peter D. Kwong. Bispecific Antibody CAP256.J3LS Targets V2-Apex and CD4-Binding Sites with High Breadth and Potency. mAbs, 15(1):2165390, 2023. PubMed ID: 36729903. Show all entries for this paper.
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