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Displaying record number 4153

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MAb ID CAP256V2LS
HXB2 Location gp160 gp160 Epitope Map
Author Location gp160
Epitope
Subtype C
Ab Type gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing P (tier2)  View neutralization details
Species (Isotype)  
Patient CAP256
Immunogen engineered
Keywords binding affinity, broad neutralizer, immunotherapy, neutralization, structure

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Isolation Paper
Zhang2022 and Baoshan Zhang. Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life, , :, 2022. Show all entries for this paper.

Cai2022 Cindy X. Cai, Nicole A. Doria-Rose, Nicole A. Schneck, Vera B. Ivleva, Brad Tippett, William R. Shadrick, Sarah O'Connell, Jonathan W. Cooper, Zachary Schneiderman, Baoshan Zhang, Daniel B. Gowetski, Daniel Blackstock, Jacob Demirji, Bob C. Lin, Jason Gorman, Tracy Liu, Yile Li, Adrian B. McDermott, Peter D. Kwong, Kevin Carlton, Jason G. Gall, and Q. Paula Lei. Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency. Sci Rep, 12(1):8433 doi, May 2022. PubMed ID: 35589938 Show all entries for this paper.

Ivleva2018 Vera B. Ivleva, Nicole A. Schneck, Deepika Gollapudi, Frank Arnold, Jonathan W. Cooper, and Q. Paula Lei. Investigation of Sequence Clipping and Structural Heterogeneity of an HIV Broadly Neutralizing Antibody by a Comprehensive LC-MS Analysis. J Am Soc Mass Spectrom, 29(7):1512-1523 doi, Jul 2018. PubMed ID: 29736600 Show all entries for this paper.

Mahomed2020 Sharana Mahomed, Nigel Garrett, Quarraisha A. Karim, Nonhlanhla Y. Zuma, Edmund Capparelli, Cheryl Baxter, Tanuja Gengiah, Derseree Archary, Natasha Samsunder, Nicole D. Rose, Penny Moore, Carolyn Williamson, Dan H. Barouch, Patricia E. Fast, Bruno Pozzetto, Catherine Hankins, Kevin Carlton, Julie Ledgerwood, Lynn Morris, John Mascola, and Salim Abdool Karim. Assessing the safety and pharmacokinetics of the anti-HIV monoclonal antibody CAP256V2LS alone and in combination with VRC07-523LS and PGT121 in South African women: study protocol for the first-in-human CAPRISA 012B phase I clinical trial. BMJ Open, 10(11):e042247 doi, Nov 2020. PubMed ID: 33243815 Show all entries for this paper.


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