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Displaying record number 4090

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MAb ID N49P6
HXB2 Location gp160 gp160 Epitope Map
Author Location  
Ab Type gp120 CD4BS, gp120 CD4i, quaternary structure
Neutralizing P (tier 2)  View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG1λ)
Patient N49
Immunogen HIV-1 infection
Country United States
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, broad neutralizer, contact residues, neutralization, structure


Showing 2 of 2 notes.


Showing 2 of 2 references.

Isolation Paper
Sajadi2018 Mohammad Mohseni Sajadi, Amir Dashti, Zahra Rikhtegaran Tehrani, William D. Tolbert, Michael S. Seaman, Xin Ouyang, Neelakshi Gohain, Marzena Pazgier, Dongkyoon Kim, Guy Cavet, Jean Yared, Robert R. Redfield, George K. Lewis, and Anthony L. DeVico. Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses. Cell, 173(7):1783-1795.e14, 14 Jun 2018. PubMed ID: 29731169. Show all entries for this paper.

Tolbert2021 William D. Tolbert, Dung N. Nguyen, Zahra Rikhtegaran Tehrani, Mohammad M. Sajadi, and Marzena Pazgier. Near-Pan-Neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer. mBio, 12(4):e0127421, 31 Aug 2021. PubMed ID: 34281393. Show all entries for this paper.

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