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Displaying record number 3979

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MAb ID	PGDM1400/PRO-140 (PGDM1400fv-PRO-140fv)
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, non-HIV: host CCR5
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)
Patient	Donor 84
Immunogen	engineered
Keywords	antibody generation, bispecific/trispecific, neutralization

Notes

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PGDM1400/PRO-140: The authors describe single-component molecules they designed that incorporate two (bispecific) or three (trispecific) bNAbs that recognize HIV Env exclusively, a bispecific CrossmAb targeting two epitopes on the major HIV coreceptor, CCR5, and bi- and trispecifics that cross-target both Env and CCR5. These newly designed molecules displayed exceptional breadth, neutralizing 98 to 100% of a 109-virus panel, as well as additivity and potency compared to those of the individual parental control IgGs. They constructed a bi-specific PGDM1400fv-PRO-140fv to simultaneously target epitopes on HIV Env and CCR5, 8 different versions of tri-specific 10E8Fab-PGT121fv-PGDM1400fv, 3 different versions of tri-specific 10E8Fab-PGT121fv-PGDM1400fv.V8, a tri-specific PRO-140Fab-PGDM1400fv-PGT121fv, and, finally, the most potent of all tri-specifics, 10E8Fab-PGDM1400fv-PRO-140fv. The tandem bispecific, PGDM1400/PRO-140 (anti-V2 apex/anti-CCR5) displayed considerable breadth of neutralization and was more effective against clade C viruses. Khan2018 (antibody generation, neutralization, bispecific/trispecific)

References

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Isolation Paper
Khan2018 Salar N. Khan, Devin Sok, Karen Tran, Arlette Movsesyan, Viktoriya Dubrovskaya, Dennis R. Burton, and Richard T. Wyatt. Targeting the HIV-1 Spike and Coreceptor with Bi- and Trispecific Antibodies for Single-Component Broad Inhibition of Entry. J. Virol., 92(18), 15 Sep 2018. PubMed ID: 29976677. Show all entries for this paper.