Found 1 matching record:
Download this epitope record as JSON.
MAb ID | polyclonal | |
---|---|---|
HXB2 Location | Env(311-322) DNA(7155..7190) |
Env Epitope Map |
Author Location | gp120( MN) | |
Epitope |
IGPGRAFYTTKN
|
Epitope Alignment
|
Ab Type | gp120 V3 // V3 glycan (V3g) | |
Neutralizing | L (MN ALA-1) | |
Species (Isotype) | guinea pig | |
Patient | ||
Immunogen | vaccine | |
Keywords |
Vaccine type | human rhinovirus 14 |
---|---|
Vaccine strain | B clade MN |
Vaccine component | Env V3 |
Showing 1 of 1 note.
Showing 1 of 1 reference.
Smith1998 A. D. Smith, S. C. Geisler, A. A. Chen, D. A. Resnick, B. M. Roy, P. J. Lewi, E. Arnold, and G. F. Arnold. Human Rhinovirus Type 14: Human Immunodeficiency Virus Type 1 (HIV-1) V3 Loop Chimeras from a Combinatorial Library Induce Potent Neutralizing Antibody Responses against HIV-1. J. Virol., 72:651-659, 1998. The tip of the MN V3 loop, IGPGRAFYTTKN, was inserted into cold-causing human rhinovirus 14 (HRV14) and chimeras were immunoselected using MAbs 447-52-D, 694/98-D, NM-01, and 59.1, for good presentation of the V3 antigenic region. The selected chimeric viruses were neutralized by anti-V3 loop MAbs. The chimeric viruses elicited potent NAbs against ALA-1 and MN in guinea pigs. PubMed ID: 9420270. Show all entries for this paper.
This is a legacy search page. It is deprecated, will receive no more updates, and will eventually be removed. Please use the new search pages.