HIV molecular immunology database
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MAb ID | Bi-ScFv (Bi-ScFvdVRC01-5X-PGT121) | |
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HXB2 Location | gp160 | gp160 Epitope Map |
Author Location | ||
Epitope |
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Ab Type | gp120 CD4BS, gp120 V3 // V3 glycan (V3g) | |
Neutralizing | P(tier 2) View neutralization details | |
Species (Isotype) | human(IgG) | |
Patient | Donor 17, NIH45 | |
Immunogen | HIV-1 infection, engineered | |
Keywords | antibody generation, bispecific/trispecific, immunotherapy, neutralization |
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Isolation Paper
Steinhardt2018
James J. Steinhardt, Javier Guenaga, Hannah L. Turner, Krisha McKee, Mark K. Louder, Sijy O'Dell, Chi-I Chiang, Lin Lei, Andrey Galkin, Alexander K. Andrianov, Nicole A. Doria-Rose, Robert T. Bailer, Andrew B. Ward, John R. Mascola, and Yuxing Li. Rational Design of a Trispecific Antibody Targeting the HIV-1 Env with Elevated Anti-Viral Activity. Nat. Commun., 9(1):877, 28 Feb 2018. PubMed ID: 29491415.
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