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Displaying record number 3933

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MAb ID	3898-1
HXB2 Location	Env	Env Epitope Map
Author Location	Env( CRF02_250)
Epitope
Subtype	CRF02_AG
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P(tier 2)
Species (Isotype)	rabbit
Patient	P3898
Immunogen	vaccine
Keywords	antibody generation, neutralization, vaccine antigen design

Vaccine Details

Vaccine type	protein
Vaccine strain	CRF02_AG clade
Vaccine component	Env trimers
Adjuvant	Iscomatrix

Notes

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3898-1: A rare glycan hole at the V2 apex is enriched in HIV isolates neutralized by inferred precursors of prototype V2-apex bNAbs. To investigate whether this feature could focus neutralizing responses onto the apex bnAb region, rabbits were immunized with soluble trimers adapted from these Envs. Potent autologous tier 2 neutralizing responses targeting basic residues in strand C of the V2 region, which forms the core epitope for V2-apex bnAbs, were observed. Neutralizing monoclonal antibodies (mAbs) derived from these animals display features promising for subsequent broadening of the response. Four human anti-V2 bnAbs (PG9, CH01, PGT145, and CAP256.09) were used as a basis of comparison. Voss2017 (antibody generation, neutralization, vaccine antigen design)

References

Showing 1 of 1 reference.

Isolation Paper
Voss2017 James E. Voss, Raiees Andrabi, Laura E. McCoy, Natalia de Val, Roberta P. Fuller, Terrence Messmer, Ching-Yao Su, Devin Sok, Salar N. Khan, Fernando Garces, Laura K. Pritchard, Richard T. Wyatt, Andrew B. Ward, Max Crispin, Ian A. Wilson, and Dennis R. Burton. Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model. Cell Rep., 21(1):222-235, 3 Oct 2017. PubMed ID: 28978475. Show all entries for this paper.