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Displaying record number 3873

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MAb ID	PCT64-18B (PCT64 18B)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

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PCT64-18B: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-18B neutralized 5 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

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Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.