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Displaying record number 3831

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MAb ID	1.7A
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Subtype	HIV-2
Ab Type	gp120 V4
Neutralizing
Species (Isotype)	human
Patient
Immunogen	virus
Keywords	SIV

Notes

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1.7A: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was resistant to anti-V4 loop human mAb, 1.7A. Isolated from homo sapien in Cole2001 (PMID 11883006). Swanstrom2016 (SIV)

References

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Swanstrom2016 Adrienne E. Swanstrom, Beth Haggarty, Andrea P. O. Jordan, Josephine Romano, George J. Leslie, Pyone P. Aye, Preston A. Marx, Andrew A. Lackner, Gregory Q. Del Prete, James E. Robinson, Michael R. Betts, David C. Montefiori, Celia C. LaBranche, and James A. Hoxie. Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus. J. Virol., 90(10):4966-4980, 15 May 2016. PubMed ID: 26937037. Show all entries for this paper.