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Displaying record number 383

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MAb ID	8/64b
HXB2 Location	gp160(300-315) DNA(7122..7169)	gp160 Epitope Map
Author Location	gp120(300-315 HXB10)
Epitope	`NNNTRKRIRIQRGPGR`	Epitope Alignment
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	L
Species (Isotype)	rat(IgM)
Patient
Immunogen	vaccine
Keywords	dendritic cells, neutralization

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade BH10
Vaccine component	gp120

Notes

Showing 4 of 4 notes.

8/64b: This Ab did not inhibit HIV-1 BaL replication in macrophages. Holl2006 (neutralization, dendritic cells)
8/64b: UK Medical Research Council AIDS reagent: ARP3036.
8/64b: The most variable amino acids in the V3 loop were replaced with serines to make the immunodominant V3 loop less immunogenic -- these changes did not affect the ability of sCD4 or MAbs to V1/V2, C1 and C4 to bind, and anti-V3 MAb 8/64b binding was abrogated by V3 serine substitutions C-term to the tip of the loop -- mice injected with serine substituted gp120 had a reduced response relative to wildtype, and no enhanced immunogenicity of conserved regions. Peet1998
8/64b: Binds to virion gp120 and neutralizes only in the presence of sCD4. McKeating1992a

References

Showing 3 of 3 references.

McKeating1992a J. A. McKeating, J. Cordell, C. J. Dean, and P. Balfe. Synergistic Interaction between Ligands Binding to the CD4 Binding Site and V3 Domain of Human Immunodeficiency Virus Type I gp120. Virology, 191:732-742, 1992. PubMed ID: 1280382. Show all entries for this paper.

Peet1998 N. M. Peet, J. A. McKeating, J. B. de Souza, I. M. Roitt, P. J. Delves, and T. Lund. The Effect of Low-Profile Serine Substitutions in the V3 Loop of HIV-1. Virology, 251:59-70, 1998. PubMed ID: 9813203. Show all entries for this paper.

Holl2006 Vincent Holl, Maryse Peressin, Thomas Decoville, Sylvie Schmidt, Susan Zolla-Pazner, Anne-Marie Aubertin, and Christiane Moog. Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells. J. Virol., 80(12):6177-6181, Jun 2006. PubMed ID: 16731957. Show all entries for this paper.