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MAb ID	G11H3 (12A-Gllh3)
HXB2 Location	Gag	Gag Epitope Map
Author Location	p17
Epitope
Ab Type
Neutralizing
Species (Isotype)	rat(IgG2a)
Patient
Immunogen
Keywords	antibody generation

Notes

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Reacted strongly with live cells, but did not possess any measurable virus-neutralizing activities. Shang1991 (antibody generation)
G11H3: This MAb is cross-reactive between p17 and mycoplasma -- this antibody binds strain specifically to the variable lipoprotein (Vlp) F of M. hyorhinis, in the region of the carboxy-terminal repeat CGGSTPTPEQGNNQGGSTPTPEQGNSQVSK -- the p17 epitope is discontinuous, but p17 and Vlp F share the tetrapeptide SQVS. Pincus1998

References

Showing 2 of 2 references.

Isolation Paper
Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.

Pincus1998 S. H. Pincus, R. L. Cole, R. Watson-McKown, A. Pinter, W. Honnen, B. Cole, and K. S. Wise. Immunologic Cross-Reaction between HIV Type 1 p17 and Mycoplasma hyorhinis Variable Lipoprotein. AIDS Res. Hum. Retroviruses, 14:419-425, 1998. PubMed ID: 9546801. Show all entries for this paper.