Search Antibody Database

Found 1 matching record:

Displaying record number 3742

Download this epitope record as JSON.

MAb ID	25-11
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Subtype	B
Ab Type	gp120 C5
Neutralizing
Species (Isotype)	rabbit
Patient	906
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, structure, vaccine antigen design, vaccine-induced immune responses

Vaccine Details

Vaccine type	protein-Ab complex
Vaccine strain	B clade JRFL, B clade YU2
Vaccine component	gp120-Mab complex
Adjuvant	Adjuplex

Notes

Showing 1 of 1 note.

25-11: Compared to patient-derived mAbs, vaccine-elicited mAbs are often less able to neutralize the virus, due to a less-effective angle of approach to the Env spike. This study engineered an immunogen consisting of the gp120 core in complex with a CD4bs mAb, 17b. Rabbits immunized with this antigen displayed earlier affinity maturation and better virus neutralization compared to those immunized with the gp120 core alone. Seven rabbit mAbs were derived from one immunized rabbit. All bound to the C5 region of gp120; all effectively competed with VRC01, but not with 17b; and all were able to neutralize some tier-1, but not tier-2, pseudoviruses. Chen2016b (antibody binding site, antibody generation, vaccine antigen design, vaccine-induced immune responses, structure)

References

Showing 1 of 1 reference.

Isolation Paper
Chen2016b Yajing Chen, Richard Wilson, Sijy O'Dell, Javier Guenaga, Yu Feng, Karen Tran, Chi-I Chiang, Heather E. Arendt, Joanne DeStefano, John R. Mascola, Richard T. Wyatt, and Yuxing Li. An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes. J. Immunol., 197(10):3982-3998, 15 Nov 2016. PubMed ID: 27815444. Show all entries for this paper.