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Displaying record number 3624

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MAb ID	NC133 (354NC133)
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Subtype	B
Ab Type
Neutralizing	P (tier 2)
Species (Isotype)	human(IgG)
Patient	EB354
Immunogen	HIV-1 infection
Keywords	antibody generation

Notes

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NC133: Neutralizing antibodies were derived from long-term non-progressing donor EB354. Samples were donated at five different time points, enabling the isolation of three bNAbs (BG1, BG18, NC37) that largely account for the donor's serologic neutralizing activity. Sequencing of viruses from the donor revealed that viruses sensitive to the antibodies coexisted with the bNAbs for long periods of time. Additional mAbs were also isolated. Freund2017 (antibody generation)

References

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Isolation Paper
Freund2017 Natalia T. Freund, Haoqing Wang, Louise Scharf, Lilian Nogueira, Joshua A. Horwitz, Yotam Bar-On, Jovana Golijanin, Stuart A. Sievers, Devin Sok, Hui Cai, Julio C. Cesar Lorenzi, Ariel Halper-Stromberg, Ildiko Toth, Alicja Piechocka-Trocha, Harry B. Gristick, Marit J. van Gils, Rogier W. Sanders, Lai-Xi Wang, Michael S. Seaman, Dennis R. Burton, Anna Gazumyan, Bruce D. Walker, Anthony P. West, Jr., Pamela J. Bjorkman, and Michel C. Nussenzweig. Coexistence of Potent HIV-1 Broadly Neutralizing Antibodies and Antibody-Sensitive Viruses in a Viremic Controller. Sci. Transl. Med., 9(373), 18 Jan 2017. PubMed ID: 28100831. Show all entries for this paper.