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Displaying record number 3278

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MAb ID PG16-iMab (PG16-ibalizumab)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Ab Type gp120 V2 // V2 glycan(V2g) // V2 apex, non-HIV: host CD4R
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human
Patient Donor 24
Immunogen  
Keywords antibody generation, bispecific/trispecific, chimeric antibody, immunotherapy, neutralization, review, subtype comparisons

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Isolation Paper
Pace2013a Craig S. Pace, Ruijiang Song, Christina Ochsenbauer, Chasity D. Andrews, David Franco, Jian Yu, Deena A. Oren, Michael S. Seaman, and David D. Ho. Bispecific Antibodies Directed to CD4 Domain 2 and HIV Envelope Exhibit Exceptional Breadth and Picomolar Potency against HIV-1. Proc. Natl. Acad. Sci. U.S.A., 110(33):13540-13545, 13 Aug 2013. PubMed ID: 23878231. Show all entries for this paper.

Bouvin-Pley2014 M. Bouvin-Pley, M. Morgand, L. Meyer, C. Goujard, A. Moreau, H. Mouquet, M. Nussenzweig, C. Pace, D. Ho, P. J. Bjorkman, D. Baty, P. Chames, M. Pancera, P. D. Kwong, P. Poignard, F. Barin, and M. Braibant. Drift of the HIV-1 Envelope Glycoprotein gp120 Toward Increased Neutralization Resistance over the Course of the Epidemic: A Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies. J. Virol., 88(23):13910-13917, Dec 2014. PubMed ID: 25231299. Show all entries for this paper.

Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.

Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.


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