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Displaying record number 3235

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MAb ID	DH228
HXB2 Location	gp160	gp160 Epitope Map
Author Location
Epitope
Subtype	C
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	P (tier 1)
Species (Isotype)	human
Patient	Donor CH505
Immunogen	HIV-1 infection
Keywords	antibody generation, antibody lineage, autologous responses, neutralization, review

Notes

Showing 2 of 2 notes.

DH228: This review discussed antibody-virus coevolution and lineage development as a path to elicit broadly neutralizing Abs. CD4bs mAbs from donor CH505 (lineages CH103 and CH235) were used as main examples. Bonsignori2017a (review, antibody lineage)
DH228: This study examined the development and co-evolution of autologous antibodies and viruses in two patients. Antibodies with limited heterologous breadth were able to potently neutralize autologous viruses, and such antibodies could select for neutralization-resistant autologous viruses implicated in transmission. Two B-cell antibodies (DH151, DH228) were isolated from chronically clade C HIV-1 infected subject CH505, known to have plasma broad neutralizing activity. These CH103-lineage, V3-antibodies were only able to neutralize a subset of autologous tier 1 viruses, no tier 2 viruses tested. T/F viruses were initially resistant to DH228, but became sensitive by wk 14. Moody2015 (antibody generation, autologous responses, neutralization)

References

Showing 2 of 2 references.

Isolation Paper
Moody2015 M. Anthony Moody, Feng Gao, Thaddeus C. Gurley, Joshua D. Amos, Amit Kumar, Bhavna Hora, Dawn J. Marshall, John F. Whitesides, Shi-Mao Xia, Robert Parks, Krissey E. Lloyd, Kwan-Ki Hwang, Xiaozhi Lu, Mattia Bonsignori, Andrés Finzi, Nathan A. Vandergrift, S. Munir Alam, Guido Ferrari, Xiaoying Shen, Georgia D. Tomaras, Gift Kamanga, Myron S. Cohen, Noel E. Sam, Saidi Kapiga, Elin S. Gray, Nancy L. Tumba, Lynn Morris, Susan Zolla-Pazner, Miroslaw K. Gorny, John R. Mascola, Beatrice H. Hahn, George M. Shaw, Joseph G. Sodroski, Hua-Xin Liao, David C. Montefiori, Peter T. Hraber, Bette T. Korber, and Barton F. Haynes. Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses. Cell Host Microbe., 18(3):354-362, 9 Sep 2015. PubMed ID: 26355218. Show all entries for this paper.

Bonsignori2017a Mattia Bonsignori, Hua-Xin Liao, Feng Gao, Wilton B. Williams, S. Munir Alam, David C. Montefiori, and Barton F. Haynes. Antibody-Virus Co-evolution in HIV Infection: Paths for HIV Vaccine Development. Immunol. Rev., 275(1):145-160, Jan 2017. PubMed ID: 28133802. Show all entries for this paper.