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Displaying record number 3219

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MAb ID	B9
HXB2 Location	gp160	gp160 Epitope Map
Author Location
Epitope
Subtype	B, C
Ab Type	gp120 CD4BS
Neutralizing	L View neutralization details
Species (Isotype)	llama
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, broad neutralizer, neutralization

Vaccine Details

Vaccine type	DNA prime with protein boost
Vaccine strain	B clade R2, C clade 96ZM651
Vaccine component	gp140

Notes

Showing 2 of 2 notes.

B9 database note: There are two entries for antibodies named B9 in the database, one raised in mouse, one in llama.
B9: Four new anti-HIV Abs were raised in llamas immunized with HIV clade B and C gp140. MAbs were selected for their ability to neutralize at least 1 tier-3 pseudovirus. Abs A14 and B9 were both derived from llama#1. All the new antibodies bound to the CD4 site and were broadly neutralizing against a panel of HIV pseudoviruses. Combinations of llama bNAbs were highly effective in neutralization of diverse strains of HIV. McCoy2014a (antibody binding site, antibody generation, neutralization, broad neutralizer)

References

Showing 1 of 1 references.

Isolation Paper
McCoy2014a Laura E. McCoy, Lucy Rutten, Dan Frampton, Ian Anderson, Luke Granger, Rachael Bashford-Rogers, Gillian Dekkers, Nika M. Strokappe, Michael S. Seaman, Willie Koh, Vanina Grippo, Alexander Kliche, Theo Verrips, Paul Kellam, Ariberto Fassati, and Robin A. Weiss. Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-binding site of HIV-1. PLoS Pathog., 10(12):e1004552, Dec 2014. PubMed ID: 25522326. Show all entries for this paper.