Search Antibody Database

Found 1 matching record:

Displaying record number 3154

Download this epitope record as JSON.

MAb ID	10M6
HXB2 Location	gp160	gp160 Epitope Map
Author Location
Epitope	(Discontinuous epitope)
Subtype	B
Ab Type	gp41-gp41 interface
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG)
Patient	Donor N152
Immunogen	HIV-1 infection
Keywords	antibody generation, neutralization

Notes

Showing 1 of 1 note.

10M6: MAb 10M6 was isolated from the same donor, N152, as MAbs 10E8 and 35O22, and is a clonal variant of 35O22. 10M6 neutralized 1/8 Env-pseudoviruses from a mini-panel. Huang2014 (antibody generation, neutralization)

References

Showing 1 of 1 reference.

Isolation Paper
Huang2014 Jinghe Huang, Byong H. Kang, Marie Pancera, Jeong Hyun Lee, Tommy Tong, Yu Feng, Ivelin S. Georgiev, Gwo-Yu Chuang, Aliaksandr Druz, Nicole A. Doria-Rose, Leo Laub, Kwinten Sliepen, Marit J. van Gils, Alba Torrents de la Peña, Ronald Derking, Per-Johan Klasse, Stephen A. Migueles, Robert T. Bailer, Munir Alam, Pavel Pugach, Barton F. Haynes, Richard T. Wyatt, Rogier W. Sanders, James M. Binley, Andrew B. Ward, John R. Mascola, Peter D. Kwong, and Mark Connors. Broad and Potent HIV-1 Neutralization by a Human Antibody That Binds the gp41-gp120 Interface. Nature, 3 Sep 2014. PubMed ID: 25186731. Show all entries for this paper.