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Displaying record number 3112

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MAb ID	PGT156 (PGT-156)
HXB2 Location	Env	Env Epitope Map
Author Location	gp120-gp41 interface
Epitope	(Discontinuous epitope)
Subtype	C
Ab Type	gp41
Neutralizing	P View neutralization details
Contacts and Features	View contacts and features
Species (Isotype)	human
Patient	Donor 31
Immunogen	HIV-1 infection
Country	United States
Keywords	antibody binding site, antibody generation, broad neutralizer, glycosylation, review

Notes

Showing 3 of 3 notes.

PGT156: This review discusses the identification of super-Abs, where and how such Abs may be best applied and future directions for the field. PGT156 was isolated from human B cell clones and is functionally similar to super Abs PGT151, 35O22 and 8ANC195. Antigenic binding site gp120–gp41 interface. Walker2018 (antibody binding site, review, broad neutralizer)
PGT156: The newly identified and defined epitope for PGT151 family MAbs binds to a site of vulnerability that does not overlap with any other bnAb epitopes. The complex PGT151 epitope requires gp160 cleavage, a properly formed quarternary gp120-gp41 interface, and fully processed gp41 glycans (complex forms). The residues that influence binding are K490, T499, R500, R503 in gp120 C5 region and K601, N607, N611, N637 in gp41. Blattner2014 (antibody binding site, glycosylation)
PGT156: 8 bNAbs (PGT151 family) were isolated from an elite neutralizer. The new bNAbs bind a previously unknown glycan-dependent epitope on the prefusion conformation of gp41. These MAbs are specific for the cleaved Env trimer and do not recognize uncleaved Env trimer. PGT156 showed modest neutralization compared to PGT151 and 152. Falkowska2014 (antibody generation, glycosylation)

References

Showing 3 of 3 references.

Isolation Paper
Falkowska2014 Emilia Falkowska, Khoa M. Le, Alejandra Ramos, Katie J. Doores, Jeong Hyun Lee, Claudia Blattner, Alejandro Ramirez, Ronald Derking, Marit J. van Gils, Chi-Hui Liang, Ryan Mcbride, Benjamin von Bredow, Sachin S. Shivatare, Chung-Yi Wu, Po-Ying Chan-Hui, Yan Liu, Ten Feizi, Michael B. Zwick, Wayne C. Koff, Michael S. Seaman, Kristine Swiderek, John P. Moore, David Evans, James C. Paulson, Chi-Huey Wong, Andrew B. Ward, Ian A. Wilson, Rogier W. Sanders, Pascal Poignard, and Dennis R. Burton. Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers. Immunity, 40(5):657-668, 15 May 2014. PubMed ID: 24768347. Show all entries for this paper.

Blattner2014 Claudia Blattner, Jeong Hyun Lee, Kwinten Sliepen, Ronald Derking, Emilia Falkowska, Alba Torrents de la Peña, Albert Cupo, Jean-Philippe Julien, Marit van Gils, Peter S. Lee, Wenjie Peng, James C. Paulson, Pascal Poignard, Dennis R. Burton, John P. Moore, Rogier W. Sanders, Ian A. Wilson, and Andrew B. Ward. Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers. Immunity, 40(5):669-680, 15 May 2014. PubMed ID: 24768348. Show all entries for this paper.

Walker2018 Laura M. Walker and Dennis R. Burton. Passive Immunotherapy of Viral Infections: `Super-Antibodies' Enter the Fray. Nat. Rev. Immunol., 18(5):297-308, May 2018. PubMed ID: 29379211. Show all entries for this paper.