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Displaying record number 2881

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MAb ID	CH49
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope	(Discontinuous epitope)
Subtype	B, CRF01_AE
Ab Type	gp120 CD4i C1 region
Neutralizing
Species (Isotype)	human(IgG1)
Patient	210884
Immunogen	vaccine
Country	Thailand
Keywords	ADCC, antibody generation, antibody sequence, review

Vaccine Details

Vaccine type	canarypox, ALVAC-HIV, AIDSVAX B/E
Vaccine strain	B clade LAI, CRF01 92TH023
Vaccine component	gp120

Notes

Showing 2 of 2 notes.

CH49: The complexity of the epitopes recognized by ADCC responses in HIV-1 infected individuals and candidate vaccine recipients is discussed in this review. CH49 is discussed as the CD4i C1 region-targeting, non-neutralizing anti-gp120 mAb exhibiting ADCC activity and having a discontinuous epitope. Pollara2013 (ADCC, review)
CH49: 23 ADCC-mediating MAbs induced by AVAC-HIV/AIDSVAX B/E vacine were isolated from 6 vaccine recipients. All donors had negative serology for HIV-1. The MAbs were modestly somatically mutated and preferentially used VH1 gene segment. 19 MAbs, including MAb CH49, were directed against conformational MAb A32-blockable gp120 epitopes. MAb CH49 was isolated from Subject 210884. Bonsignori2012a (ADCC, antibody generation, antibody sequence)

References

Showing 2 of 2 references.

Isolation Paper
Bonsignori2012a Mattia Bonsignori, Justin Pollara, M. Anthony Moody, Michael D. Alpert, Xi Chen, Kwan-Ki Hwang, Peter B. Gilbert, Ying Huang, Thaddeus C. Gurley, Daniel M. Kozink, Dawn J. Marshall, John F. Whitesides, Chun-Yen Tsao, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Jerome H. Kim, Nelson L. Michael, Georgia D. Tomaras, David C. Montefiori, George K. Lewis, Anthony DeVico, David T. Evans, Guido Ferrari, Hua-Xin Liao, and Barton F. Haynes. Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family. J. Virol., 86(21):11521-11532, Nov 2012. PubMed ID: 22896626. Show all entries for this paper.

Pollara2013 Justin Pollara, Mattia Bonsignori, M. Anthony Moody, Marzena Pazgier, Barton F. Haynes, and Guido Ferrari. Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity (ADCC) Responses. Curr. HIV Res., 11(5):378-387, Jul 2013. PubMed ID: 24191939. Show all entries for this paper.