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Displaying record number 2851

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MAb ID GE136
HXB2 Location Env Env Epitope Map
Author Location ( YU2)
Epitope
Subtype B
Ab Type gp120 CD4BS
Neutralizing P
Species (Isotype) macaque
Patient  
Immunogen vaccine
Keywords antibody binding site, antibody generation, antibody lineage, antibody sequence, structure, vaccine antigen design, vaccine-induced immune responses

Vaccine Details

Vaccine type gp140F (fused form, no gp120–gp41 cleavage site)
Vaccine strain B clade YU2
Vaccine component Env
Adjuvant Abisco-100, CpG oligodeoxynucleotides

Notes

Showing 3 of 3 notes.

References

Showing 4 of 4 references.

Isolation Paper
Sundling2010 Christopher Sundling, Mattias N. E. Forsell, Sijy O'Dell, Yu Feng, Bimal Chakrabarti, Srinivas S. Rao, Karin Loré, John R. Mascola, Richard T. Wyatt, Iyadh Douagi, and Gunilla B. Karlsson Hedestam. Soluble HIV-1 Env Trimers in Adjuvant Elicit Potent and Diverse Functional B Cell Responses in Primates. J. Exp. Med., 207(9):2003-2017, 30 Aug 2010. PubMed ID: 20679401. Show all entries for this paper.

Chen2016b Yajing Chen, Richard Wilson, Sijy O'Dell, Javier Guenaga, Yu Feng, Karen Tran, Chi-I Chiang, Heather E. Arendt, Joanne DeStefano, John R. Mascola, Richard T. Wyatt, and Yuxing Li. An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes. J. Immunol., 197(10):3982-3998, 15 Nov 2016. PubMed ID: 27815444. Show all entries for this paper.

Dai2015 Kaifan Dai, Linling He, Salar N. Khan, Sijy O'Dell, Krisha McKee, Karen Tran, Yuxing Li, Christopher Sundling, Charles D. Morris, John R. Mascola, Gunilla B. Karlsson Hedestam, Richard T. Wyatt, and Jiang Zhu. Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis. MBio, 6(6):e01375-15, 3 Nov 2015. PubMed ID: 26530382. Show all entries for this paper.

Sundling2012 Christopher Sundling, Yuxing Li, Nick Huynh, Christian Poulsen, Richard Wilson, Sijy O'Dell, Yu Feng, John R. Mascola, Richard T. Wyatt, and Gunilla B. Karlsson Hedestam. High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site. Sci. Transl. Med., 4(142):142ra96, 11 Jul 2012. PubMed ID: 22786681. Show all entries for this paper.


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