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MAb ID	I181
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Subtype	A
Ab Type	gp120 V2-V3
Neutralizing
Species (Isotype)	human(IgG)
Patient
Immunogen	HIV-1 infection
Keywords	vaccine-induced immune responses

Notes

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I181: The RV144 trial demonstrated 31% vaccine efficiency and antibodies against the HIV envelop V1/V2 inversely correlated with infection. This paper showed that vaccine induced immune responses against V1/V2 selectively impact or sieve HIV-1 break through viruses and the immune responses were associated with two signatures in V1/V2 at AA position 169 and 181. Rolland2012 (vaccine-induced immune responses)

References

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Rolland2012 Morgane Rolland, Paul T. Edlefsen, Brendan B. Larsen, Sodsai Tovanabutra, Eric Sanders-Buell, Tomer Hertz, Allan C. deCamp, Chris Carrico, Sergey Menis, Craig A. Magaret, Hasan Ahmed, Michal Juraska, Lennie Chen, Philip Konopa, Snehal Nariya, Julia N. Stoddard, Kim Wong, Hong Zhao, Wenjie Deng, Brandon S. Maust, Meera Bose, Shana Howell, Adam Bates, Michelle Lazzaro, Annemarie O'Sullivan, Esther Lei, Andrea Bradfield, Grace Ibitamuno, Vatcharain Assawadarachai, Robert J. O'Connell, Mark S. deSouza, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Merlin L. Robb, Jason S. McLellan, Ivelin Georgiev, Peter D. Kwong, Jonathan M. Carlson, Nelson L. Michael, William R. Schief, Peter B. Gilbert, James I. Mullins, and Jerome H. Kim. Increased HIV-1 Vaccine Efficacy against Viruses with Genetic Signatures in Env V2. Nature, 490(7420):417-420, 18 Oct 2012. PubMed ID: 22960785. Show all entries for this paper.