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Displaying record number 2823

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MAb ID	3BC329
HXB2 Location	gp160	gp160 Epitope Map
Author Location
Epitope
Ab Type	gp120 close to V3, gp120 close to CD4i
Neutralizing
Species (Isotype)	human(IgG)
Patient
Immunogen	HIV-1 infection
Country	Germany
Keywords	antibody generation, neutralization

Notes

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3BC329: A single-cell Ab cloning method is described to isolate neutralizing Abs using truncated gp160 transfected cells as bait. Among the 15 Abs reported, only two, but not 3BC329 are found to be broadly neutralizing and bind to a novel conformational HIV-1 spike epitope. Klein2012 (antibody generation, neutralization)

References

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Isolation Paper
Klein2012 Florian Klein, Christian Gaebler, Hugo Mouquet, D. Noah Sather, Clara Lehmann, Johannes F. Scheid, Zane Kraft, Yan Liu, John Pietzsch, Arlene Hurley, Pascal Poignard, Ten Feizi, Lynn Morris, Bruce D. Walker, Gerd Fätkenheuer, Michael S. Seaman, Leonidas Stamatatos, and Michel C. Nussenzweig. Broad Neutralization by a Combination of Antibodies Recognizing the CD4 Binding Site and a New Conformational Epitope on the HIV-1 Envelope Protein. J. Exp. Med., 209(8):1469-1479, 30 Jul 2012. PubMed ID: 22826297. Show all entries for this paper.