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Displaying record number 2715

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MAb ID	2D7 (2D7-V4)
HXB2 Location	gp160(394-401) DNA(7404..7427)	gp160 Epitope Map
Author Location	gp120( IIIB)
Research Contact	Drs B Vestegaard and E Hulgaard
Epitope	TWFNSTWS	Epitope Alignment
Subtype	B
Ab Type	gp120 V4
Neutralizing
Species (Isotype)	mouse(IgG2b)
Patient
Immunogen	vaccine
Keywords	antibody interactions

Vaccine Details

Notes

Showing 2 of 2 notes.

• 2D7: Database Note: There are 2 antibodies named 2D7 in this database. The antibody described in this entry is reagent ARP3028 at the UK Centre for AIDS Reagents (https://www.nibsc.org/CFAR%20Datasheets/3028.pdf). The source is listed as Drs B Vestegaard and E Hulgaard. The specificity is listed as the V4 epitope of HIV-1 IIIB gp120 (TWFNSTWS).
• 2D7: The capacity of 2D7 to block completely the activity of the anti-HIV peptide T20 was investigated. T20 inhibited the fusion or syncytia formation between co-cultured CHO-WT cells expressing HIV-1 HXB2 envelope glycoprotein on their surface and HeLaT4 cells. 2D7 was not able to block the anti-fusion effect of T20. Vincent2012 (antibody interactions)

References

Showing 1 of 1 references.

Vincent2012 Nadine Vincent and Etienne Malvoisin. Ability of Antibodies Specific to the HIV-1 Envelope Glycoprotein to Block the Fusion Inhibitor T20 in a Cell-Cell Fusion Assay. Immunobiology, 217(10):943-950, Oct 2012. PubMed ID: 22387075. Show all entries for this paper.