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Displaying record number 2664

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MAb ID m66.6 (M66.6)
HXB2 Location gp160(663-666)
gp160 Epitope Map
Author Location  
Epitope LDKW Epitope Alignment
LDKW epitope logo
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing View neutralization details
Species (Isotype) human(IgG1)
Patient SC44
Immunogen HIV-1 infection
Country Netherlands
Keywords antibody binding site, antibody generation, antibody interactions, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, memory cells, neutralization, review, structure, vaccine antigen design, vaccine-induced immune responses


Showing 5 of 5 notes.


Showing 5 of 5 references.

Isolation Paper
Zhu2011 Zhongyu Zhu, Haiyan Rebekah Qin, Weizao Chen, Qi Zhao, Xiaoying Shen, Robert Schutte, Yanping Wang, Gilad Ofek, Emily Streaker, Ponraj Prabakaran, Genevieve G. Fouda, Hua-Xin Liao, John Owens, Mark Louder, Yongping Yang, Kristina-Ana Klaric, M. Anthony Moody, John R. Mascola, Jamie K. Scott, Peter D. Kwong, David Montefiori, Barton F. Haynes, Georgia D. Tomaras, and Dimiter S. Dimitrov. Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies. J. Virol., 85(21):11401-11408, Nov 2011. PubMed ID: 21880764. Show all entries for this paper.

Bonsignori2012b Mattia Bonsignori, S. Munir Alam, Hua-Xin Liao, Laurent Verkoczy, Georgia D. Tomaras, Barton F. Haynes, and M. Anthony Moody. HIV-1 Antibodies from Infection and Vaccination: Insights for Guiding Vaccine Design. Trends Microbiol., 20(11):532-539, Nov 2012. PubMed ID: 22981828. Show all entries for this paper.

Georgiev2013 Ivelin S. Georgiev, Nicole A. Doria-Rose, Tongqing Zhou, Young Do Kwon, Ryan P. Staupe, Stephanie Moquin, Gwo-Yu Chuang, Mark K. Louder, Stephen D. Schmidt, Han R. Altae-Tran, Robert T. Bailer, Krisha McKee, Martha Nason, Sijy O'Dell, Gilad Ofek, Marie Pancera, Sanjay Srivatsan, Lawrence Shapiro, Mark Connors, Stephen A. Migueles, Lynn Morris, Yoshiaki Nishimura, Malcolm A. Martin, John R. Mascola, and Peter D. Kwong. Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization. Science, 340(6133):751-756, 10 May 2013. PubMed ID: 23661761. Show all entries for this paper.

Haynes2012 Barton F. Haynes, Garnett Kelsoe, Stephen C. Harrison, and Thomas B. Kepler. B-Cell-Lineage Immunogen Design in Vaccine Development with HIV-1 as a Case Study. Nat. Biotechnol., 30(5):423-433, May 2012. PubMed ID: 22565972. Show all entries for this paper.

Ofek2014 Gilad Ofek, Brett Zirkle, Yongping Yang, Zhongyu Zhu, Krisha McKee, Baoshan Zhang, Gwo-Yu Chuang, Ivelin S. Georgiev, Sijy O'Dell, Nicole Doria-Rose, John R. Mascola, Dimiter S. Dimitrov, and Peter D. Kwong. Structural Basis for HIV-1 neutralization By 2F5-Like Antibodies m66 and m66.6. J. Virol., 88(5):2426-2441, Mar 2014. PubMed ID: 24335316. Show all entries for this paper.

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