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Displaying record number 2658

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MAb ID	CH11
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp41
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords	neutralization

Notes

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CH11: The ability of donor CH0219, from whom CH01-CH04 and VRC-CH30-34 MAbs were isolated, to generate additional antibody specificities with some degree of HIV-1 neutralization activity was formally proven by the isolation from IgG+ memory B-cell cultures of anti-V3 loop (CH19) and anti-gp41 (CH11) mAbs. These MAbs had narrow spectra of neutralization: CH19 neutralized exclusively clade B tier 1 viruses and CH11 neutralized only two tier 2 viruses out of 97 tested. Bonsignori2012 (neutralization)

References

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Bonsignori2012 Mattia Bonsignori, David C. Montefiori, Xueling Wu, Xi Chen, Kwan-Ki Hwang, Chun-Yen Tsao, Daniel M. Kozink, Robert J. Parks, Georgia D. Tomaras, John A. Crump, Saidi H. Kapiga, Noel E. Sam, Peter D. Kwong, Thomas B. Kepler, Hua-Xin Liao, John R. Mascola, and Barton F. Haynes. Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design. J. Virol., 86(8):4688-4692, Apr 2012. PubMed ID: 22301150. Show all entries for this paper.