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Displaying record number 248

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MAb ID	Ab4
HXB2 Location	Rev(72-91) DNA(8516..8575)	Rev Epitope Map
Author Location	Rev(72-91 BRU)
Research Contact	Tony Lowe and Jonathan Karn, MRC Center, Cambridge
Epitope	`PLQLPPLERLTLDCNEDCGT`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine component	Rev

Notes

Showing 2 of 2 notes.

Ab4: This epitope is similar fragments of the human protein Epidermal growth factor receptor substrate 15, EPVPMSLPPA, and Insulin-like growth factor binding protein complex acid labile chain precursor, QPPGLERLWLEGNPWDCG. Maksiutov2002
Ab4: The binding site overlaps the nuclear export signal -- binding was not blocked by bound HIV RNA and may be accessible for protein interaction. Henderson1997

References

Showing 2 of 2 references.

Henderson1997 B. R. Henderson and P. Percipalle. Interactions between HIV Rev and Nuclear Import and Export Factors: The Rev Nuclear Localisation Signal Mediates Specific Binding to Human Importin-beta. J. Mol. Biol., 274:693-707, 1997. PubMed ID: 9405152. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.