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Displaying record number 2476

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MAb ID	0.5δ (3D6)
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Subtype	B
Ab Type	gp120 CD4BS
Neutralizing	P (tier 2)
Species (Isotype)	human(IgG1λ)
Patient	KTS376
Immunogen	HIV-1 infection
Country	Japan
Keywords	antibody generation, binding affinity, mimics, neutralization

Notes

Showing 2 of 2 notes.

0.5δ(3D6): B-cell clones derived from a long-term non-progressive patient were selected for MAbs reactive to gp120. These MAbs bound to several complementary regions of gp120 and synergistically neutralized a wide range of HIV subtypes. This could be an alternative method to induction of bNAbs. Median neutralization potency against 4/11 laboratory and primary strains was high, between 0.05-10 µl, medium for 1/11 strains; and high-medium against 1 each subtype B of a standard panel of 27 HIV-1. RamirezValdez2015 (neutralization, binding affinity)
0.5δ: MAbs were established from a patient with long-term nonprogressive illness. B cells from the patient’s PBMC were transformed by Epstein-Barr virus, followed by cloning. At low concentrations, combinations of 0.5δ with the small CD4-mimicking compound NBD-556 showed additive effects on the inhibitory concentrations against HIV IIIB. Yoshimura2010 (antibody generation, mimics)

References

Showing 2 of 2 references.

Isolation Paper
Yoshimura2010 Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura, and Shuzo Matsushita. Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds. J. Virol., 84(15):7558-7568, Aug 2010. PubMed ID: 20504942. Show all entries for this paper.

RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.