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Displaying record number 2470

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MAb ID	1d9
HXB2 Location	gp160	gp160 Epitope Map
Author Location	gp41
Epitope
Ab Type	gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	antibody generation, binding affinity

Vaccine Details

Vaccine type	other
Vaccine component	mimotopes

Notes

Showing 2 of 2 notes.

1d9: Database comment: the database contains distinct antibodies named 1D9 and 1d9. Also, Ab 1D9D5 is referred to as 1D9 by Theisen2006.
1d9: 2F5 epitope was transplanted into 5 select protein scaffolds by computational techniques. The five resultant 2F5-epitope scaffolds (ES1-ES5) showed high affinity for 2F5MAb. 1d9 was isolated from mice immunized with 2F5-epitope scaffold ES5. 1d9 showed high affinity for both 2F5 epitope and the scaffolds. Ofek2010a (antibody generation, binding affinity)

References

Showing 1 of 1 references.

Isolation Paper
Ofek2010a Gilad Ofek, F. Javier Guenaga, William R. Schief, Jeff Skinner, David Baker, Richard Wyatt, and Peter D. Kwong. Elicitation of Structure-Specific Antibodies by Epitope Scaffolds. Proc. Natl. Acad. Sci. U.S.A., 107(42):17880-17887, 19 Oct 2010. PubMed ID: 20876137. Show all entries for this paper.