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MAb ID	Ab2
HXB2 Location	Rev(32-50) DNA(8396..8452)	Rev Epitope Map
Author Location	Rev(32-49 BRU)
Research Contact	Tony Lowe and Jonathan Karn, MRC Center, Cambridge
Epitope	`EGTRQARRNRRRWRERQR`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine component	Rev

Notes

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Ab2: The Ab2 binding site overlaps the nuclear localization signal -- Ab2 binding to Rev was blocked by bound HIV RNA -- the cellular protein importin-beta can bind in this Arg rich region -- atypically, the Rev binds specifically to importin-beta, but not to the importin-beta-importin-alpha dimer. Henderson1997

References

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Henderson1997 B. R. Henderson and P. Percipalle. Interactions between HIV Rev and Nuclear Import and Export Factors: The Rev Nuclear Localisation Signal Mediates Specific Binding to Human Importin-beta. J. Mol. Biol., 274:693-707, 1997. PubMed ID: 9405152. Show all entries for this paper.