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Displaying record number 244

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MAb ID	3H6
HXB2 Location	Rev(38-43) DNA(8414..8431)	Rev Epitope Map
Author Location	Rev(38-44)
Epitope	RRNRRR	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen	vaccine
Keywords	antibody generation

Vaccine Details

Notes

Showing 3 of 3 notes.

• 3H6: This epitope is similar to a fragment of the human protein Complement 4 (containing C4A anaphlylatoxin), GRRNRRRR. Maksiutov2002
• 3H6: Directed against nucleolar localization/RRE binding domain -- antigenic domain tentative, MAb failed to bind a RRNRRR Rev deletion mutant. Orsini1995 (antibody generation)
• 3H6 database comment: There is another MAb with this ID that recognizes gp41.

References

Showing 2 of 2 references.

Isolation Paper
Orsini1995 M. J. Orsini, A. N. Thakur, W. W. Andrews, M.-L. Hammarskjold, and D. Rekosh. Expression and Purification of the HIV Type 1 Rev Protein Produced in Escherichia coli and Its Use in the Generation of Monoclonal Antibodies. AIDS Res. Hum. Retroviruses, 11:945-953, 1995. PubMed ID: 7492441. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.