HIV molecular immunology database

 

Search Antibody Database

Found 1 matching record:

Displaying record number 241

Download this epitope record as JSON.

MAb ID L-anti-Tat
HXB2 Location Tat Tat Epitope Map
Author Location Tat
Research Contact AGMED, Inc., Bedford, MA USA
Epitope
Ab Type  
Neutralizing L P (when lipidated)
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Tat

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Cruikshank1997 W. W. Cruikshank, S. R. Doctrow, M. S. Falvo, K. Huffman, J. Maciaszek, G. Viglianti, J. Raina, H. Kornfeld, and B. Malfroy. A Lipidated Anti-Tat Antibody Enters Living Cells and Blocks HIV-1 Viral Replication. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 14:193-203, 1997. A technique was developed to lipidate antibodies and allow intracellular delivery; lipidated anti-Tat inhibited viral replication of several HIV-1 isolates by approximately 85\% as shown by increased viability of infected cells and decreased reverse transcriptase activity. PubMed ID: 9117450. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health