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MAb ID	L-anti-Tat
HXB2 Location	Tat	Tat Epitope Map
Author Location	Tat
Research Contact	AGMED, Inc., Bedford, MA USA
Epitope
Ab Type
Neutralizing	L P (when lipidated)
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine component	Tat

Notes

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L-anti-Tat: Lipidated antibody can be taken up by cells and effectively block IIIB and primary virus HIV-1 replication in actively and latently infected cells. Cruikshank1997

References

Showing 1 of 1 reference.

Cruikshank1997 W. W. Cruikshank, S. R. Doctrow, M. S. Falvo, K. Huffman, J. Maciaszek, G. Viglianti, J. Raina, H. Kornfeld, and B. Malfroy. A Lipidated Anti-Tat Antibody Enters Living Cells and Blocks HIV-1 Viral Replication. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 14:193-203, 1997. A technique was developed to lipidate antibodies and allow intracellular delivery; lipidated anti-Tat inhibited viral replication of several HIV-1 isolates by approximately 85\% as shown by increased viability of infected cells and decreased reverse transcriptase activity. PubMed ID: 9117450. Show all entries for this paper.