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Displaying record number 237

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MAb ID 2D9E7
HXB2 Location Tat(49-86)
DNA(5975..6045,8379..8421)
Tat Epitope Map
Author Location Tat
Epitope RKKRRQRRRPPQGSQTHQVSLSKQPTSQSRGDPTGPKE Epitope Alignment
Ab Type C-term
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Tat

Notes

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References

Showing 1 of 1 reference.

Valvatne1996 H. Valvatne, A. M. Szilvay, and D. E. Helland. A Monoclonal Antibody Defines a Novel HIV Type 1 Tat Domain Involved in Trans-Cellular Trans-Activation. AIDS Res. Hum. Retroviruses, 12:611-619, 1996. CAT and beta-galactosidase assays, and immunofluorescence analysis were used to study the cellular uptake of the HIV-1 Tat protein. A MAb binding to the basic domain and the RGD sequence inhibits trans- activation by exogenous Tat. The inhibition of the cellular uptake of Tat by an anti-Tat monoclonal antibody and by the serum components implies specific binding of Tat to the cell membrane. PubMed ID: 8743086. Show all entries for this paper.


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