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Displaying record number 236

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MAb ID 4B4C4 (4B4)
HXB2 Location Tat(49-86)
DNA(5975..6045,8379..8421)
Tat Epitope Map
Author Location Tat
Epitope RKKRRQRRRPPQGSQTHQVSLSKQPTSQSRGDPTGPKE Epitope Alignment
Ab Type C-term
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Tat

Notes

Showing 1 of 1 note.

References

Showing 2 of 2 reference.

Valvatne1996 H. Valvatne, A. M. Szilvay, and D. E. Helland. A Monoclonal Antibody Defines a Novel HIV Type 1 Tat Domain Involved in Trans-Cellular Trans-Activation. AIDS Res. Hum. Retroviruses, 12:611-619, 1996. CAT and beta-galactosidase assays, and immunofluorescence analysis were used to study the cellular uptake of the HIV-1 Tat protein. A MAb binding to the basic domain and the RGD sequence inhibits trans- activation by exogenous Tat. The inhibition of the cellular uptake of Tat by an anti-Tat monoclonal antibody and by the serum components implies specific binding of Tat to the cell membrane. PubMed ID: 8743086. Show all entries for this paper.

Jensen1997 T. H. Jensen, A. Jensen, A. M. Szilvay, and J. Kjems. Probing the Structure of HIV-1 Rev by Protein Footprinting of Multiple Monoclonal Antibody-Binding Sites. FEBS Lett., 414:50-54, 1997. Rev was mapped using MAb protein footprinting, which gave results that agreed well with peptide mapping, but was useful for identifying a discontinuous interaction between two regions. Footprints supported a previously proposed structure (Auer et al., Biochemistry, 33 (1994) 2988-2996) predicting that a helix-loop-helix motif in Rev brings the termini of the protein into proximity. PubMed ID: 9305730. Show all entries for this paper.


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