HIV molecular immunology database
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|MAb ID||anti-HIV-1 RT|
|HXB2 Location||Pol||Pol Epitope Map|
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Showing 3 of 3 references.
Veronese1986 F. di Marzo Veronese, T. D. Copeland, A. L. DeVico, R. Rahman, S. Oroszlan, R. C. Gallo, and M. G. Sarngadharan. Characterization of Highly Immunogenic p66/p51 as the Reverse Transcriptase of HTLV-III/LAV. Science, 231:1289-1291, 1986. This study identified the 66 and 51 kilodaltons bands in western blots as RT. Enzymatic activity was shown, and the protein was defined by Edmund N-terminal degradation and comparison to HIV-1 pol nucleotide translation. A mouse hybridoma was generated that inhibited enzyme activity. PubMed ID: 2418504. Show all entries for this paper.
Maciejewski1995 J. P. Maciejewski, F. F. Weichold, N. S. Young, A. Cara, D. Zella, M. S. Reitz, Jr., and R. C. Gallo. Intracellular Expression of Antibody Fragments Directed against HIV Reverse Transcriptase Prevents HIV Infection In Vitro. Nat. Med., 1:667-673, 1995. Transduction of genes that encode and express anti-RT Fab inhibit the enzyme, making cells resistant to HIV infection by blocking an early stage of viral replication. The authors propose that if transduction of a vector into lymphohaematopoietic stem cells or mature lymphocytes becomes feasible, gene transfer therapy has promise for treating AIDS. PubMed ID: 7585149. Show all entries for this paper.
Wainberg1995 M. A. Wainberg and Z. Gu. Targeting HIV Reverse Transcriptase in Novel Ways. Nat. Med., 1:628-629, 1995. Commentary on Maciejewski et al., 1995. PubMed ID: 7585138. Show all entries for this paper.