HIV molecular immunology database
Found 1 matching record:
Download this epitope record as JSON.
|MAb ID||MAb 35|
|Pol Epitope Map|
Showing 4 of 4 notes.
Showing 3 of 3 references.
Barsov1996 E. V. Barsov, W. E. Huber, J. Marcotrigiano, P. K. Clark, A. D. Clark, E. Arnold, and S. H. Hughes. Inhibition of Human Immunodeficiency Virus Type 1 Integrase by the Fab Fragment of a Specific Monoclonal Antibody Suggests that Different Multimerization States Are Required for Different Enzymatic Functions. J. Virol., 70:4484-4494, 1996. MAb 35 does not inhibit HIV-1 IN, but Fab 35 inhibits 3'-end processing, strand transfer and disintegration. This appears to be through interfering with multimerization, and suggests that the C-terminal region is important for IN function. PubMed ID: 8676473. Show all entries for this paper.
Acel1998 A. Acel, B. E. Udashkin, M. A. Wainberg, and E. A. Faust. Efficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 Integrase. J. Virol., 72:2062-71, 1998. Intrinsic polymerase activity that can catalyze gap repair was described for HIV Integrase. This activity was inhibited by the MAb 35, that binds to KAKIIRDYGK at the C-term end of Integrase. PubMed ID: 9499061. Show all entries for this paper.
Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.