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MAb ID MAb 35
HXB2 Location Pol(979-988)
DNA(5019..5048)
Pol Epitope Map
Author Location Integrase(264-273)
Epitope KAKIIRDYGK Epitope Alignment
KAKIIRDYGK epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgGκ)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 4 of 4 notes.

References

Showing 3 of 3 references.

Barsov1996 E. V. Barsov, W. E. Huber, J. Marcotrigiano, P. K. Clark, A. D. Clark, E. Arnold, and S. H. Hughes. Inhibition of Human Immunodeficiency Virus Type 1 Integrase by the Fab Fragment of a Specific Monoclonal Antibody Suggests that Different Multimerization States Are Required for Different Enzymatic Functions. J. Virol., 70:4484-4494, 1996. MAb 35 does not inhibit HIV-1 IN, but Fab 35 inhibits 3'-end processing, strand transfer and disintegration. This appears to be through interfering with multimerization, and suggests that the C-terminal region is important for IN function. PubMed ID: 8676473. Show all entries for this paper.

Acel1998 A. Acel, B. E. Udashkin, M. A. Wainberg, and E. A. Faust. Efficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 Integrase. J. Virol., 72:2062-71, 1998. Intrinsic polymerase activity that can catalyze gap repair was described for HIV Integrase. This activity was inhibited by the MAb 35, that binds to KAKIIRDYGK at the C-term end of Integrase. PubMed ID: 9499061. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.


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