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Displaying record number 2061

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MAb ID	Fab 8060
HXB2 Location	Env	Env Epitope Map
Author Location	gp41
Epitope
Ab Type
Neutralizing
Species (Isotype)
Patient
Immunogen	in vitro stimulation or selection
Keywords	binding affinity, neutralization

Notes

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Fab 8060: 8060 was derived by affinity maturation of the parent Fab 3674. 8060 bound to the same epitope as the parental Fab and showed improved binding affinity towards the target peptide compared to the parent Fab 3674. This was one of three maturated Abs that showed significant increases in both breadth and potency of neutralization against primary isolates of subtypes B and C, compared to the parental Fab. The improved neutralization activity was greater for the Fabs in monovalent than in bivalent formats. Gustchina2009 (neutralization, binding affinity)

References

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Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.