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Displaying record number 2047

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MAb ID	17G12
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	C
Ab Type
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	antibody generation, neutralization, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	C clade 97ZA012
Vaccine component	gp140ΔCFI

Notes

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17G12: This MAb was cloned from mouse hybridoma after immunization of the animals with subtype C Env protein. 17G12 weakly cross-reacted with all of the tested HIV-1 subtypes and with SIVcpz indicating conservation of some epitopes following cross-species transmission. 17G12 did not neutralize any of the tier 1 and tier 2 subtype B and C viruses. This suggests that the conserved epitope targeted by this Ab is not accessible on the functional Env proteins. Gao2009 (antibody generation, neutralization, variant cross-reactivity)

References

Showing 1 of 1 reference.

Isolation Paper
Gao2009 Feng Gao, Richard M. Scearce, S. Munir Alam, Bhavna Hora, Shimao Xia, Julie E. Hohm, Robert J. Parks, Damon F. Ogburn, Georgia D. Tomaras, Emily Park, Woodrow E. Lomas, Vernon C. Maino, Susan A. Fiscus, Myron S. Cohen, M. Anthony Moody, Beatrice H. Hahn, Bette T. Korber, Hua-Xin Liao, and Barton F. Haynes. Cross-reactive Monoclonal Antibodies to Multiple HIV-1 Subtype and SIVcpz Envelope Glycoproteins. Virology, 394(1):91-98, 10 Nov 2009. PubMed ID: 19744690. Show all entries for this paper.