Search Antibody Database

Found 1 matching record:

Displaying record number 2034

Download this epitope record as JSON.

MAb ID	ED49
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Ab Type	gp120 CD4i
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords	neutralization

Notes

Showing 2 of 2 notes.

ED49: LANL database note: This monoclonal antibody is a CHAVI reagent (http://chavi.org/); Species: human; Category: CD4i MAbs; Contact person: James Robinson
ED49: Two chimeras were constructed from a new HIV-2KR.X7 proviral scaffold where the V3 region was substituted with the V3 from HIV-1 YU2 and Ccon, generating subtype B and C HIV-2 V3 chimera. Both chimera, and the wildtype HIV-2KR and its derivatives HIV-2KR.X4 and HIV-2KR.X7 were resistant to neutralization by ED49. Davis2009 (neutralization)

References

Showing 1 of 1 references.

Davis2009 Katie L. Davis, Frederic Bibollet-Ruche, Hui Li, Julie M. Decker, Olaf Kutsch, Lynn Morris, Aidy Salomon, Abraham Pinter, James A. Hoxie, Beatrice H. Hahn, Peter D. Kwong, and George M. Shaw. Human Immunodeficiency Virus Type 2 (HIV-2)/HIV-1 Envelope Chimeras Detect High Titers of Broadly Reactive HIV-1 V3-Specific Antibodies in Human Plasma. J. Virol., 83(3):1240-1259, Feb 2009. PubMed ID: 19019969. Show all entries for this paper.