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Displaying record number 202

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MAb ID 4F6
HXB2 Location Pol(771-817)
Pol Epitope Map
Author Location Integrase(56-102 HXB2)
Subtype B
Ab Type Integrase catalytic core
Species (Isotype) mouse(IgG1κ)
Immunogen vaccine

Vaccine Details

Vaccine type protein
Vaccine strain B clade HXB2
Vaccine component Int


Showing 2 of 2 notes.


Showing 2 of 2 references.

Haugan1995 I. R. Haugan, B. M. Nilsen, S. Worland, L. Olsen, and D. E. Helland. Characterization of the DNA-Binding Activity of HIV-1 Integrase Using a Filter Binding Assay. Biochem. Biophys. Res. Commun., 217:802-810, 1995. PubMed ID: 8554601. Show all entries for this paper.

Nilsen1996 B. M. Nilsen, I. R. Haugan, K. Berg, L. Olsen, P. O. Brown, and D. E. Helland. Monoclonal Antibodies against Human Immunodeficiency Virus Type 1 Integrase: Epitope Mapping and Differential Effects of Integrase Activities In Vitro. J. Virol., 70:1580-1587, 1996. In this study, 17 anti-integrase murine Mabs were generated and epitopes were mapped by deletion mutations and peptide scanning. The ability of MAb binding to inhibit (or stimulate) end-processing, DNA joining, reintegration, and disintegration enzyme functions it in vitro was determined. PubMed ID: 8627677. Show all entries for this paper.

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