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MAb ID	2E3
HXB2 Location	Pol(716-731) DNA(4230..4277)	Pol Epitope Map
Author Location	Integrase(1-16 HXB2)
Epitope	FLDGIDKAQDEHEKYH	Epitope Alignment
Subtype	B
Ab Type	N-term
Neutralizing
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 2 of 2 notes.

• 2E3: One of a large set of MAbs that interact with the N-terminal part of integrase: 1C4, 2C11, 2E3, 3E11, 3F9, 5F8, 6G5, 7B6, 7C6 -- these MAbs inhibit end processing and DNA joining, but had little effect on integration activities. Nilsen1996
• 2E3: There are two MAbs called 2E3 -- the other one binds to Nef. Ovod1992

References

Showing 2 of 2 references.

Nilsen1996 B. M. Nilsen, I. R. Haugan, K. Berg, L. Olsen, P. O. Brown, and D. E. Helland. Monoclonal Antibodies against Human Immunodeficiency Virus Type 1 Integrase: Epitope Mapping and Differential Effects of Integrase Activities In Vitro. J. Virol., 70:1580-1587, 1996. In this study, 17 anti-integrase murine Mabs were generated and epitopes were mapped by deletion mutations and peptide scanning. The ability of MAb binding to inhibit (or stimulate) end-processing, DNA joining, reintegration, and disintegration enzyme functions it in vitro was determined. PubMed ID: 8627677. Show all entries for this paper.

Ovod1992 V. Ovod, A. Lagerstedt, A. Ranki, F. O. Gombert, R. Spohn, M. Tahtinen, G. Jung, and K. J. Krohn. Immunological Variation and Immunohistochemical Localization of HIV-1 Nef Demonstrated with Monoclonal Antibodies. AIDS, 6:25-34, 1992. Ten anti-Nef MAbs were generated and mapped. Nef is expressed in two isomorphic forms, and was shown to be expressed mainly in the Golgi complex and at the nuclear membrane, but occasionally x in the nucleus, particularly in MT-4 cells. PubMed ID: 1371924. Show all entries for this paper.