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Displaying record number 1877

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MAb ID	3F9
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	C
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords	neutralization, variant cross-reactivity

Vaccine Details

Vaccine type	protein
Vaccine strain	C clade 97CN54
Vaccine component	other

Notes

Showing 2 of 2 notes.

3F9 database note: There are two distinct antibodies named 3F9 in the database.
3F9: Mice were immunized with a construct of the outer domain (OD) of gp120 of subtype C fused with Fc, and MAbs specific for the CN54 OD were derived by exhaustive screening of the mice sera. The OD-specific 3F9 MAb cross-competed with three other newly identified OD-specific MAbs: 4E1, 1G12, 1H8, but did not cross-compete with 4D3 (bridging sheet) or the V3-specific 2B7 and 4E5. 3F9 showed no neutralization of the three isolates tested, CN54, MN, and 93MW965.26. Chen2008a (neutralization, variant cross-reactivity)

References

Showing 1 of 1 references.

Chen2008a Hongying Chen, Xiaodong Xu, Hsin-Hui Lin, Ssu-Hsien Chen, Anna Forsman, Marlen Aasa-Chapman, and Ian M. Jones. Mapping the Immune Response to the Outer Domain of a Human Immunodeficiency Virus-1 Clade C gp120. J. Gen. Virol., 89(10):2597-2604, Oct 2008. PubMed ID: 18796729. Show all entries for this paper.