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Displaying record number 1860

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MAb ID A12 (VHH A12)
HXB2 Location Env Env Epitope Map
Author Location Env
Research Contact Robin A Weiss, University Colledge London, London, UK, r.weiss@ucl.ac.uk
Epitope
Ab Type gp120 CD4BS
Neutralizing View neutralization details
Species (Isotype) llama
Patient  
Immunogen vaccine
Keywords antibody binding site, antibody generation, binding affinity, glycosylation, kinetics, neutralization, structure, subtype comparisons, vaccine antigen design, variant cross-reactivity

Vaccine Details

Vaccine type protein
Vaccine strain C clade 97CN54
Vaccine component gp120

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Isolation Paper
Forsman2008 Anna Forsman, Els Beirnaert, Marlén M. I. Aasa-Chapman, Bart Hoorelbeke, Karolin Hijazi, Willie Koh, Vanessa Tack, Agnieszka Szynol, Charles Kelly, Áine McKnight, Theo Verrips, Hans de Haard, and Robin A Weiss. Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120. J. Virol., 82(24):12069-12081, Dec 2008. PubMed ID: 18842738. Show all entries for this paper.

Balla-Jhagjhoorsingh2013 Sunita S. Balla-Jhagjhoorsingh, Davide Corti, Leo Heyndrickx, Elisabeth Willems, Katleen Vereecken, David Davis, and Guido Vanham. The N276 Glycosylation Site Is Required for HIV-1 Neutralization by the CD4 Binding Site Specific HJ16 Monoclonal Antibody. PLoS One, 8(7):e68863, 2013. PubMed ID: 23874792. Show all entries for this paper.

Hinz2010 Andreas Hinz, David Lutje Hulsik, Anna Forsman, Willie Wee-Lee Koh, Hassan Belrhali, Andrea Gorlani, Hans de Haard, Robin A. Weiss, Theo Verrips, and Winfried Weissenhorn. Crystal Structure of the Neutralizing Llama V(HH) D7 and Its Mode of HIV-1 gp120 Interaction. PLoS One, 5(5):e10482, 2010. PubMed ID: 20463957. Show all entries for this paper.

Koh2010 Willie W. L. Koh, Soren Steffensen, Maria Gonzalez-Pajuelo, Bart Hoorelbeke, Andrea Gorlani, Agnieszka Szynol, Anna Forsman, Marlén M. I. Aasa-Chapman, Hans de Haard, Theo Verrips, and Robin A. Weiss. Generation of a Family-Specific Phage Library of Llama Single Chain Antibody Fragments That Neutralize HIV-1. J. Biol. Chem., 285(25):19116-19124, 18 Jun 2010. PubMed ID: 20400507. Show all entries for this paper.

Meyerson2013 Joel R. Meyerson, Erin E. H. Tran, Oleg Kuybeda, Weizao Chen, Dimiter S. Dimitrov, Andrea Gorlani, Theo Verrips, Jeffrey D. Lifson, and Sriram Subramaniam. Molecular Structures of Trimeric HIV-1 Env in Complex with Small Antibody Derivatives. Proc. Natl. Acad. Sci. U.S.A., 110(2):513-518, 8 Jan 2013. PubMed ID: 23267106. Show all entries for this paper.

Strokappe2012 Nika Strokappe, Agnieszka Szynol, Marlèn Aasa-Chapman, Andrea Gorlani, Anna Forsman Quigley, David Lutje Hulsik, Lei Chen, Robin Weiss, Hans de Haard, and Theo Verrips. Llama Antibody Fragments Recognizing Various Epitopes of the CD4bs Neutralize a Broad Range of HIV-1 Subtypes A, B and C. PLoS One, 7(3):e33298, 15 Mar 2012. PubMed ID: 22438910. Show all entries for this paper.


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