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MAb ID m36 (m36.4, M36)
HXB2 Location Env Env Epitope Map
Author Location gp120
Research Contact Dimiter S Dimitrov, National Institutes of Health, Fredrick, MD.
Epitope (Discontinuous epitope)
Subtype B
Ab Type gp120 C3, gp120 CD4i
Neutralizing P
Contacts and Features View contacts and features
Species (Isotype) human
Immunogen in vitro stimulation or selection
Keywords antibody binding site, antibody generation, binding affinity, bispecific/trispecific, broad neutralizer, computational epitope prediction, immunotherapy, mimotopes, neutralization, review, structure, variant cross-reactivity


Showing 7 of 7 notes.


Showing 7 of 7 references.

Isolation Paper
Chen2008 Weizao Chen, Zhongyu Zhu, Yang Feng, and Dimiter S. Dimitrov. Human Domain Antibodies to Conserved Sterically Restricted Regions on gp120 as Exceptionally Potent Cross-Reactive HIV-1 Neutralizers. Proc. Natl. Acad. Sci. U.S.A., 105(44):17121-17126, 4 Nov 2008. PubMed ID: 18957538. Show all entries for this paper.

Chen2009b Weizao Chen and Dimiter S. Dimitrov. Human Monoclonal Antibodies and Engineered Antibody Domains as HIV-1 Entry Inhibitors. Curr. Opin. HIV AIDS, 4(2):112-117, Mar 2009. PubMed ID: 19339949. Show all entries for this paper.

Chen2010 Weizao Chen, Xiaodong Xiao, Yanping Wang, Zhongyu Zhu, and Dimiter S. Dimitrov. Bifunctional Fusion Proteins of the Human Engineered Antibody Domain m36 with Human Soluble CD4 Are Potent Inhibitors of Diverse HIV-1 Isolates. Antiviral Res., 88(1):107-115, Oct 2010. PubMed ID: 20709110. Show all entries for this paper.

Chen2014a Weizao Chen, Yang Feng, Ponraj Prabakaran, Tianlei Ying, Yanping Wang, Jianping Sun, Camila D. S. Macedo, Zhongyu Zhu, Yuxian He, Victoria R. Polonis, and Dimiter S. Dimitrov. Exceptionally Potent and Broadly Cross-Reactive, Bispecific Multivalent HIV-1 Inhibitors Based on Single Human CD4 and Antibody Domains. J. Virol., 88(2):1125-1139, Jan 2014. PubMed ID: 24198429. Show all entries for this paper.

Khan2018 Salar N. Khan, Devin Sok, Karen Tran, Arlette Movsesyan, Viktoriya Dubrovskaya, Dennis R. Burton, and Richard T. Wyatt. Targeting the HIV-1 Spike and Coreceptor with Bi- and Trispecific Antibodies for Single-Component Broad Inhibition of Entry. J. Virol., 92(18), 15 Sep 2018. PubMed ID: 29976677. Show all entries for this paper.

Meyerson2013 Joel R. Meyerson, Erin E. H. Tran, Oleg Kuybeda, Weizao Chen, Dimiter S. Dimitrov, Andrea Gorlani, Theo Verrips, Jeffrey D. Lifson, and Sriram Subramaniam. Molecular Structures of Trimeric HIV-1 Env in Complex with Small Antibody Derivatives. Proc. Natl. Acad. Sci. U.S.A., 110(2):513-518, 8 Jan 2013. PubMed ID: 23267106. Show all entries for this paper.

Wan2013 Chao Wan, Jianping Sun, Weizao Chen, Xiaohui Yuan, Huihui Chong, Ponraj Prabakaran, Dimiter S. Dimitrov, and Yuxian He. Epitope Mapping of M36, a Human Antibody Domain with Potent and Broad HIV-1 Inhibitory Activity. PLoS One, 8(6):e66638, 2013. PubMed ID: 23776690. Show all entries for this paper.

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